Molecular Formula: C₉H₁₁F₂N₃O₄.HCl
Synonyms: Gemcitabine HCl; 2',2'-Difluorodeoxycytidine monohydrochloride; 2'-Deoxy-2',2'-difluorocytidine monohydrochloride; 2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
Appearance: White crystalline granular, odorless
Molecular Weight: 299.66
Boiling Point: 482.7 °C at 760 mmHg
Melting Point: >250°C dec
Flash Point: 245.7 °C
Solubility: In water, 5.13X10+4 mg/L at 25 deg C (est)
Biological Activity: Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .
Usage: An antineoplastic