Molecular Formula: C22H24ClFN4O3
Synonyms: N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; ZD1839; 4-(3-Chloro-4-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; Irressat; Gefitinib (JAN/USAN); 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-; ZD 1839; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-;
Appearance: Light-Yellow Crystalline Powder
Molecular Weight: 446.9
Density: 1.322g/cm3
Boiling Point: 586.8 °C at 760 mmHg
Melting Point: 119-120
Flash Point: 308.7 °C
Refractive index: 1.621
Biological Activity: Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23-79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts.
Usage: An antineoplastic
|