EINECS: 217-780-5
Molecular Formula: C₁₇H₂₁NO₃•HBr;C₁₇H₂₂BrNO₃
Synonyms: galantamine hydrobromide; Galantamine Hbr
Appearance: white to offf-white powder
Molecular Weight: 368.27
Boiling Point: 439.3 °C at 760 mmHg
Melting Point: 256 °C
Flash Point: 439.3°C at 760 mmHg
Storage Temperature: ?20°C
Refractive index: -95 ° (C=1.4, H2O)
Solubility: Fairly soluble in hot water; freely soluble in alcohol, acetone, chloroform. Less sol in benzene, ether.
Biological Activity: Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Usage: A selective acetylcholinesterase inhibitor