Molecular Formula: C₄₅H₅₄N₄O₈.2(C₄H₆O₆)
Synonyms: Vinorelbine ditartrate (JAN); Navelbine (TN); Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt); KW 2307; Navelbine; Nor-5-anhydrovinblastine ditartrate; C-Norvincaleukoblastine, 3,4-didehydro-4-deoxy-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (salt); Vinorelbine ditartrate; Vinorelbine ditartate; 3', 4'-didehydro-4'-deoxy- C '-norvincaleukoblastine; Vinorelbineditartrate; Vinorelbine tartrate, USP;
Appearance: white to off-white crystalline powder
Molecular Weight: 1079.10594
Density: 1.36g/cm3
Melting Point: 181-183°C
Storage Temperature: 2-8°C
Refractive index: 1.675
Solubility: 10 mg/mL in water
Biological Activity: Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC 50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC 50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
Usage: An antineoplastic