Molecular Formula: C₁₂H₂₁NO₈S
Synonyms: McN-4853; Epitomax; 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranos sulfamate; a-D-Fructopyranose,2,3:4,5-bis-O-(1-methylethylidene)-,sulfamate; Tipiramato [Spanish]; Topamax; Topiramate [USAN:BAN:INN]; 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate; Topiramate; Topamax; RWJ-17021-000; 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate; Topiramate (JAN/USAN); Tipiramate [French]; Topamax (TN);
Appearance: white to off-white crystalline powder
Molecular Weight: 339.36
Density: 1.336 g/cm3
Boiling Point: 438.7 °C at 760 mmHg
Melting Point: 125℃
Flash Point: 219.1 °C
Storage Temperature: 2-8°C
Refractive index: 1.497
Solubility: DMSO Solubility : ~44 mg/mL
Biological Activity: Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Stability: Stable if stored as directed.
Usage: Used as an anticonvulsant