| Product name |
Pyrimethamine |
| CAS No. |
58-14-0 |
| Molecular Structure |
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| Uasage |
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EINECS: 200-364-2
Molecular Formula: C12H13ClN4
Synonyms: 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;
Appearance: white powder
Molecular Weight: 248.71
Density: 1.305g/cm3
Boiling Point: 491.5°Cat760mmHg
Melting Point: 233-234℃
Flash Point: 251°C
Storage Temperature: 0-6°C
Refractive index: 1.655
Solubility: <0.01 g/100 mL at 21 oC
Biological Activity: Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).
Stability: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
Usage: Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial
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