Molecular Formula: C₈H₁₄N₂O₄Pt
Synonyms: Eloxatin; 1-OHP; (1R,2R)-cyclohexane-1,2-diamine; oxalic acid; platinum(+2) cation; Eloxatin (TN); Trans-l-diaminocyclohexane oxalatoplatinum; Platinum, (1,2-cyclohexanediamine-N,N)(ethanedioato(2-)-O,O-, (SP-4-2-(1R-trans))-; Platinum, [ (1R,2R)-1,2-cyclohexanediamine-.kappa.N, .kappa.N][ethanedioato(2-)-.kappa.O1,.kappa.O2]-,(SP-4-2)-; (SP-4-2-(1R-trans))-(1,2-Cyclohexanediamine-N,N)(ethanedioato(2-)-O,O)platinum; RP 54780; Oxalatoplatinum; Oxaliplatin EP5;
Appearance: White Crystalline Solid
Molecular Weight: 397.28576
Boiling Point: 193.6 °C at 760 mmHg
Flash Point: 75 °C
Solubility: Soluble
Biological Activity: Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Stability: Stable. Store cool. Incompatible with oxidizing agents.
Usage: A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA