EINECS: 288-060-6
Molecular Formula: C₁₇H₁₉N₃
Synonyms: 6-Azamianserin; Avanza; Mepirzapin; Mepirzepine; Mirtaz 15; Mirtazepine; Mirtazipine; Norset; Org 3770; Promyrtil; Remergil; Remergon; Remeron; Remeron SolTab; Rexer; Zispin; 2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-;
Appearance: white solid
Molecular Weight: 265.35286
Density: 1.22g/cm3
Boiling Point: 432.4 °C at 760 mmHg
Melting Point: 114-116°C
Flash Point: 215.3 °C
Storage Temperature: Store at RT
Solubility: DMSO: ~8 mg/mL, soluble
Biological Activity: Antidepressant agent; potent 5-HT 2 , 5-HT 3 and histamine H 1 receptor antagonist and moderately potent α 2 -adrenoceptor antagonist (pK i values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α 2 -adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pK i values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo .