EINECS: 278-903-6
Molecular Formula: C₁₂H₉N₃O
Synonyms: 3-CYANO-6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE; 6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE-3-CARBONITRILE; 1,6-DIHYDRO-2-METHYL-6-OXO-(3,4'-BIPYRIDINE)-5-CARBONITRILE; 1,6-DIHYDRO-2-METHYL-6-OXO-3,4-BIPYRIDINE-5-CARBONITRILe; 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTINONITRILE; 4’-bipyridine)-5-carbonitrile,1,6-dihydro-2-methyl-6-oxo-( win47203; Milirinone; MilrinoneUsDmf; 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBONITRILE(MILRINONE); 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)- NICOTINONITRILES(MILRINONE); 6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
Appearance: Off-white solid
Molecular Weight: 211.21936
Density: 1.28 g/cm3
Boiling Point: 448.7 °C at 760 mmHg
Melting Point: >3000C
Flash Point: 225.2 °C
Storage Temperature: 2-8°C
Solubility: DMSO: >10 mg/mL
Biological Activity: Potent cAMP phosphodiesterase inhibitor (IC 50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo . Also available as part of the Phosphodiesterase Inhibitor Tocriset? .
Stability: Stable. Incompatible with strong oxidizing agents.
Usage: Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic