EINECS: 233-570-6
Molecular Formula: C₂₃H₂₈ClN₃O₅S
Synonyms: Urea,1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl- (8CI); 1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl]-3-cyclohexylurea; Adiab; Antibet; Apo-Glibenclamide; Betanaz; Betanese 5; Calabren; Cytagon; Daonil; Daonil N; Debtan; Dia-basan; Diabeta; Diabiphage; Dibelet; Duraglucon; Euglucan; Euglucon; Euglucon 5; Euglykon; GBN 5; Gilemal; Gl; Glamide; Gliban; Gliben; Gliben-Puren N; Glibenclamide; Glibenil; Glibens; Glibesyn; Glibet; Glibetic; Glibil; Glibomet; Gliboral; Glicem; Glidiabet; Glucobene;
Appearance: white or almost white crystalline podwer
Molecular Weight: 494
Density: 1.36 g/cm3/sup>
Boiling Point: °Cat760mmHg
Melting Point: 173-175°C
Storage Temperature: 2-8°C
Refractive index: 1.628
Solubility: Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96%) and in methanol. Practically insoluble in ether. It dissolves in dilute solutions of alkali hydroxides. Biological Activity: ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in intracellular Ca 2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC 50 of 20 μ M.
Stability: Stable at normal temperatures and pressures.
Usage: A second generation sulfonylurea with hypoglycemic activity