EINECS: 207-174-9
Molecular Formula: C₁₅H₁₀O₅
Synonyms: 4H-1-Benzopyran-4-one, 5, 7-dihydroxy-3- (4-hydroxyphenyl)-; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one; Prunetol; Isoflavone, 4,5,7-trihydroxy-; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-; SIPI 807-1; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5-18-04-00594 (Beilstein Handbook Reference); C.I. 75610; NPI 031L; 4,5,7-Trihydroxyisoflavone; 4',5,7-trihydroxyisoflavone; 4,5, 7-Trihydroxyisoflavone; Genisteol; Baichanin A; Differenol A; 4H-1-Benzopyran-4-one,5,7-dihydroxy-3- (4-hydroxyphenyl)-; Genisterin; Sophoricol; 5,7,4-Trihydroxyisoflavone; Genistein 4,5,7-Trihydroxyisoflavone;
Appearance: Yellow Crystalline Solid
Molecular Weight: 270.24
Density: 1.548 g/cm3
Boiling Point: 555.5 °C at 760 mmHg
Melting Point: 297-298℃ Flash Point: 217.1 °C
Storage Temperature: 20°C
Refractive index: 1.732
Solubility: insoluble Biological Activity: Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset .
Stability: No data.
Usage: Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell