EINECS: 219-089-4
Molecular Formula: C₈H₁₂N₄O₄
Synonyms: s-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-(7CI,8CI); 2-Desoxy-5-azacytidine; 2'-Deoxy-5-azacytidine; 5-Azadeoxycytidine; DAC; Dacogen; 1,3,5-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-; b-Decitabine;
Appearance: white crystalline powder
Molecular Weight: 228.20528
Density: 1.9 g/cm3
Boiling Point: 485.8 °C at 760 mmHg
Melting Point: 200℃ (dec.)
Flash Point: 247.6 °C
Storage Temperature: 20°C
Refractive index: 1.779
Solubility: acetic acid/water (1:1): 50 mg/mL
Biological Activity: Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
Stability: Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
Usage: Decitabine (CAS NO.2353-33-5) is used as a drug.