EINECS: 200-015-4
Molecular Formula: C7H15Cl2N2O2P
Synonyms: 2H-1,3,2-Oxazaphosphorin-2-amine,N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate (9CI); 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide,monohydrate (8CI); 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxidemonohydrate; Endoxanmonohydrate; 2H-1,3,2-Oxazaphosphorin-2-amine,N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, hydrate (1:1);
Appearance: White to Off-White Solid
Molecular Weight: 279.13
Boiling Point: 336.1 °C at 760 mmHg
Melting Point: 49-51 °C
Flash Point: 157.1 °C
Storage Temperature: 2-8°C
Solubility: H2O: 0.1 g/mL, clear, colorless
Stability: No data.
Usage: It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
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