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EINECS: 200-598-5
Molecular Formula: C22H25NO6
Synonyms: Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-; Colchicine (8CI); Benzo[a]heptalene, acetamide deriv.; (-)-Colchicine; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; Colchineos; Colchisol; Colcin; Colsaloid; Condylon; NSC 757
Appearance: yellow powder
Molecular Weight: 399.44
Density: 1.32 g/cm3
Boiling Point: RELATIVE DENSITY
Melting Point: 150-160℃
Flash Point: 392.9°C
Alpha: -250 o (C=1, ALCOHOL)
Storage Temperature: Poison room
Refractive index: 1.584
Biological Activity: Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
Stability: Stable. Light sensitive. Incompatible with strong oxidizing agents.
Usage: An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal
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