EINECS: 239-733-8
Molecular Formula: Cl₂H₆N₂Pt
Synonyms: Neoplatin; Platosin; cis-dichlorodi-ammine platinum(ii); cis-Diammineplatinum(II) dichloride; cis-Dichlorodiamminoplatinum(II); CPDD; cisPt(II); cis-Platinum(II) diaminodichloride; Platinum(II), diamminedichloro-, cis-; Biocisplatinum; Cisplatyl; DDP (antitumor agent); Cisplatinum; azane; platinum(+2) cation; dichloride;
Appearance: Orange-yellow to deep yellow solid or powder
Molecular Weight: 300.05
Density: 3.7
Melting Point: 270℃
Storage Temperature: Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed. Solubility:<0.1 g/100 mL at 19 oC in water
Biological Activity: Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis.
Stability: Stable. Incompatible with oxidizing agents, aluminium, antioxidants.
Usage: Used as an antineoplastic