Molecular Formula: C₂₄H₂₆N₂O₄
Synonyms: 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano; COREG; DIMITONE; DQ-2466; DILATREND; BM-14190; 1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL; 1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol; Carvedilo; CarvedilolC24H26N204; Carvediloledmf/Gmpep5; CarvedilolEdmf/Gmp; CarvedilolEp5
Appearance: colourless crystalline powder
Molecular Weight: 406.48
Density: 1.25 g/cm3
Boiling Point: 655.2 °C at 760 mmHg
Melting Point: 113-117°C
Flash Point: 350.1 °C
Storage Temperature: Store at +4°C
Solubility: Insoluble
Biological Activity: Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.
Usage: A nonselective -adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.