Molecular Formula: C₂₄H₃₆O₅ 
Synonyms: MK-803; Belvas; (1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate; Rodatin; Paschol; Artein; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; Sivlor; MK 803; Mevinolin; Prestwick_819; Antibiotic MB 530B; Lestatin; Colevix; Lovastation; Mevinacor; Lovasterol;
Appearance: White solid
Molecular Weight: 404.54
Density: 1.12 g/cm3
Boiling Point: 559.2 oC at 760 mmHg
Melting Point: 175℃
Flash Point: 185.3 oC
Storage Temperature: 2-8°C
Refractive index: 320 ° (C=0.5, CH3CN)
Solubility: 0.0004 mg/mL at 25 oC
Biological Activity: Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
Usage: An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase