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EINECS: 444-280-6
Molecular Formula: C20H16N2O4
Synonyms: 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothecin; Camptothecin, Camptotheca acuminata; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin,95%; Camptothecin; 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin
Appearance: light yellow crystal powde
Molecular Weight: 348.36
Density: 1.51 g/cm3
Boiling Point: 264°C
Melting Point: 260°C
Flash Point: 411.6 °C
Storage Temperature: 2-8°C
Refractive index: 1.787
Solubility: insoluble in water,chloroform/methanol (4:1): 4 mg/mL
Biological Activity: Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
Usage: Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
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