Molecular Formula:C₂₈H₂₈O₃
Synonyms:2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo(3.3.1.1(sup 3,7))dec-1-ylphenyl)-; Adapalene (JAN/USAN); Differin (TN); CD 271; 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid; 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid; Adapalene [USAN:BAN:INN]; Differin; Adapalenum [INN-Latin]; Dermatological, a Topical Treatment for Acne; Adapalene(106685-40-9); Adapaleno [INN-Spanish]; 2-Naphthalenecarboxylic acid,6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec- 1-ylphenyl)-;
Appearance:white to off-white crystalline powder
Molecular Weight:412.52
Density:1.233 g/cm³
Boiling Point:606.3 °C at 760 mmHg
Melting Point:319-322 °C
Flash Point:205.9 °C
Storage Temperature:Store in original container in a cool dark place.
Refractive index:1.654
Solubility:Insoluble
Biological Activity:Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β , RAR γ , RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro . Displays comedolytic activity.
Usage:Retinoid selective for retinoic acid receptor (RAR) subtypes ?and . Antiacne